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KMID : 0882420120820030357
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Korean Journal of Medicine
2012 Volume.82 No. 3 p.357 ~ p.361
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A Case of Pulmonary Alveolar Proteinosis Improved with Inhaled Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
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Kang Bo-Hyoung
Lee Ho-Su
Lee Yu-Mi
Park So-Eun
Kim Woo-Sung
Kim Dong-Soon
Song Jin-Woo
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Abstract
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Pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by the accumulation of lipoproteinaceous material within the alveoli. Several studies have recently found that autoantibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF) play a major role in the pathogenesis of idiopathic PAP. Consequently, inhaled or systemic injection of GM-CSF has been suggested as a promising treatment for PAP. A 54-year-old male visited our hospital for progressive dyspnea. Four years earlier, he was diagnosed with PAP based on a surgical lung biopsy in another institution. Whole-lung lavage was performed four times before he visited our hospital. We administered high-dose inhaled GM-CSF therapy for 12 weeks followed by 12 weeks of low-dose therapy. After the GM-CSF treatment, the patient’s symptoms, lung function, and radiological findings were improved significantly.
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KEYWORD
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Pulmonary alveolar proteinosis, Granulocyte-macrophage colony-stimulating factor, Administration, inhalation
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